2021 Mercedes-Benz E350 E 350 4MATIC
Sedan · 255 hp · 25 mpg combined
Sticker from
$56,750Factory MSRP, base configuration
Market
Too few listings to publish a market price.
Own one? Yours has a number of its own.
Track what yours is worthA fresh estimate every month, in one short email. Not an offer to buy.Start tracking40 factory options, from $50 to $4,900.
designo Exclusive Nappa Leather Package$4,900
Premium Package$2,300
Driver Assistance Package$1,950
AIR BODY CONTROL$1,900
Active Multicontour Front Seats w/Massage$1,320
AMG® Line Exterior w/Night Package$1,150
Acoustic Comfort Package$1,100
Head-Up Display$1,100
Warmth and Comfort Package$1,050
Panorama Roof$1,000
Exterior Lighting Package$900
AMG® Line Exterior$750
Rear Side Airbags$700
Wood/Leather Steering Wheel$600
4-Pack LED Logo Projectors$550
19" AMG® Twin 5-Spoke Wheels$500
19" 10-Spoke Wheels$500
19" AMG® Twin 5-Spoke Wheels w/Black Accents$500
Ventilated Front Seats$450
Power Rear-Window Sunshade$440
Rear Spoiler$350
Topstitched MB-Tex Dash Trim$350
Illuminated Door Sills$350
Black Rear Spoiler$350
MBUX Augmented Video for Navigation$350
Comfort Box$300
LED Logo Projectors$275
Gloss Black Exterior Mirror Housings$250
Heated Steering Wheel$250
Adaptive Highbeam Assist$250
MBUX Interior Assistant$200
Dashcam$200
Inductive Wireless Charging w/NFC Pairing$200
Wheel Locks$150
Household-Type 115V Power Outlet$115
Chrome Door Handle Inserts$100
Rear Cabin USB-C Ports$50
18" AMG® 5-Spoke Wheels—
18" AMG® 5-Spoke Wheels w/Black Accents—
18" Multispoke Wheels—
Which E350 is right for you?
Two trims, $54,250 to $56,750. Tap one to open it.
Bar heights follow the price. The widest step is $2,500, from E 350 to E 350 4MATIC.
The numbers.
One configuration: all-wheel drive, 9-speed automatic.
255hp2.0L four-cylinder turbo
273lb-ftTorque
25mpgCombined · 22 city · 30 highway
AWD9-speed shiftable automatic
5Seats
13.1 cu ftCargo volume
3,924 lbsCurb weight
125 standard items.
Five groups, sized by how much is in each.
- 4 one-touch power windows
- 1st row power glass moonroof
- hands-free entry
- Heated mirrors
- Rear head room
- Rear leg room
- Rear shoulder room
- Split-folding rear seatback
- folding center armrest
- Front head room
- Front leg room
- Front shoulder room
- leatherette
- bucket front seats
- 10-way power driver seat
- height adjustable driver seat
- Driver seat with power adjustable lumbar support
- driver seat thigh extension
- 3 memorized driver seat settings
- 10-way power passenger seat
- height adjustable passenger seat
- Passenger seat with power adjustable lumbar support
- Passenger seat thigh extension
- 3 memorized passenger seat settings
- multi-level heated driver seat
- multi-level heated passenger seat
- trip computer
- compass
- external temperature display
- tachometer
- clock
- keyless ignition
- tilt and telescopic steering wheel
- Transmission, cruise and audio controls on steering wheel
- electric power steering
- rear view camera
- cruise control
- universal remote transmitter (for garage door, security system, etc.)
- front and rear cupholders
- front and rear door pockets
- overhead console with storage
- front seatback storage
- leather steering wheel
- Dual zone front climate control
- rear ventilation ducts
- interior air filtration
- Dual illuminating vanity mirrors
- electrochromatic inside rearview mirror
- turn signal in mirrors
- Length
- Overall width with mirrors
- Overall width without mirrors
- Height
- Wheelbase
- Cargo capacity, all seats in place
- Manufacturer 0-60 mph acceleration time
- Turning circle
- Ground clearance
- Curb weight
- Country of final assembly
- Fuel type
- EPA city/highway MPG
- EPA combined MPG
- Range in miles (city/hwy)
- Fuel tank capacity
- four-wheel independent suspension
- Front and rear stabilizer bar
- Base engine size
- Cylinders
- Base engine type
- Horsepower
- Torque
- Valves
- Cam type
- Valve timing
- direct injection
- Transmission
- Drive type
- Center limited slip differential
- alloy wheels
- 18 x 8.0 in. wheels
- 245/45R18 tires
- Run flat tires
- blind spot warning accident avoidance system
- Driver attention alert
- pre-collision safety system
- post-collision safety system
- dual front side-mounted airbags
- front and rear head airbags
- Passenger airbag occupant sensing deactivation
- stability control
- traction control
- child seat anchors
- Rear door child safety locks
- 4-wheel ABS
- brake drying
- Front and rear ventilated disc brakes
- emergency braking preparation
- Emergency braking assist
- tire pressure monitoring
- dusk sensing headlamps
- auto delay off headlamps
- LED headlamp
- daytime running lights
- Turn signal mirrors
- 2 front headrests
- Front power adjustable headrests
- 3 rear headrests
- Rear height adjustable headrests
- Rear center 3-point belt
- remote anti-theft alarm system
- engine immobilizer
- Emergency Service
- Airbag Deployment Notification
- Vehicle Alarm notification
- Stolen Vehicle Tracking/Assistance
- Roadside Assistance
- Concierge Service
- Destination guidance (also Turn-by-Turn Navigation)
- Destination Download
- AM/FM stereo
- 2 subwoofer(s)
- Android Auto/Apple CarPlay
- USB connection
- auxiliary audio input and USB with external media control
13 interiors
- Macchiato Beige/Magma Grey Nappa
- Black Nappa
- Macchiato Beige/Magma Grey
- designo Macchiato Beige/Saddle Brown Exclusive Nappa
- Nut Brown/Black Nappa
- Black
- Neva Grey/Magma Grey
- Neva Grey/Magma Grey
- Nut Brown/Black
- Macchiato Beige/Black
- Macchiato Beige/Black
- Nut Brown/Black
- Black
Premium leather or leatherette or leather.
11 factory paints
- Selenite Grey Metallic
- designo Diamond White Metallic
- Cirrus Silver Metallic
- Polar White
- Mojave Silver Metallic
- Lunar Blue Metallic
- designo Selenite Grey Magno
- Black
- Graphite Grey Metallic
- Obsidian Black Metallic
- designo Cardinal Red Metallic
Safety and recalls
6 recall campaigns on file.
Recalls are settled per car, not per model. Check the one you are buying.
NHTSA has not published ratings for the 2021 E350. A model year is often unrated for a year or more after it goes on sale.
NHTSA NCAP · checked Oct 2026
Factory coverage.
It runs from the first sale date, not the model year.
Basic
4 yr / 50,000 mi
Powertrain
4 yr / 50,000 mi
Rust
4 yr / 50,000 mi
Roadside
4 yr / 50,000 mi
Sold1 yr2 yr3 yr4 yr
Sponsored · Insurance offers
What would this E350 cost to insure?
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Other years of the E350 E 350 4MATIC.
2022 E350 E 350 4MATIC
$57,450$700 more11 colors · starting MSRP2020 E350 E 350 4MATIC
$56,550$200 less9 colors · starting MSRP2023 E350 E 350 4MATIC
$59,250$2,500 more11 colors · starting MSRPStarting MSRP is before destination, taxes and dealer fees.